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In research settings, NNMT inhibition is commonly used to explore how altering that branch point can shift the balance of methyl donor consumption, influence measurable pathway intermediates, and change downstream signatures that relate to energy handling, lipid pathways, and mitochondrial capacity depending on model and assay conditions

International Journal of Molecular Sciences , 19(7), 2102

doi: 10.1002/14651858.CD015588.pub2